1134 (Po) Pantoprazole Versus Omeprazole At Laryngopharyngeal Reflux

Conference: 
Author(s): 

A.G. Vitas, C.F. Tsatsalidis, A.G. Papadaki, P.C. Georgoudis, A.G. Vitas, S.P. Zanos, P.C. Sahpatzidou
Community centre of Doksato, General Hospital of Drama, Health centre of Kato Neurokopi, Greece

Text: 

BACKGROUND/AIM:
The Aim of this original clinical controlled trial was the evaluation of therapeutic approach between two PPIs for the management of laryngopharyngeal reflux (LR) in humans.
METHODS/MATERIAL:
The population of study it was constituted a random sample of 94 adults in that was placed the diagnosis .active LR. and they did not make use PPIs or gastro kinetic drugs in the last half-year period. They were matching according to their personal characteristics in two groups. In the 1st group were administrated pantoprazole 40 mg/24h and the 2nd Omeprazole 40 mg/24h, for three possessed months period. Was held follow up in 30 and 90 days, where became evaluation of therapeutic protocols based to Vitas Score and to endoscopic elements of indirect laryngoscopes. For the statistical analysis was used the SPSS.
RESULTS:
The 46 (48.9%) patients were males with mean age (MA) 45.7+12.63 years and the 48 (51%) females with MA 45.9+13.61 years old (p NS). The score values between two groups from the beginning of study (BS) also as they were shaped in the follow up, as well as the results of comparisons, mentioned in table:

Groups

Score BS

Score after 30 days

Score after 90 days

1st
IInd

172.114
169.917

101.381
127.862

33.80
76.38

P

NS

0.001

0.0002

CONCLUSION:
The available data suggest that administration of 40 mg/24h pantoprazole was had better clinical but also endoscopic results comparative 40 mg/24h Omeprazole, in the adults with LP who was studied.

 

Literature: 

1134 (PO) PANTOPRAZOLE VERSUS OMEPRAZOLE AT LARYNGOPHARYNGEAL REFLUX