120 Relation Of Circadian Blood Pressure Variations And Quality Of Life In Untreated Essential Hypertensive Subjects

Anargiros Mariolis
Aims: To study the effects of diurnal blood pressure (BP) variations upon quality of life (QOL) in untreated subjects with moderate essential hypertension (EH)
Design and Methods:
Towards this end, 102 subjects (aged 53?11 years) with stage I-II EH were classified as dippers and non-dippers according to the diurnal variation of >10% between mean daytime and night-time systolic and diastolic BP in 24-h non-invasive ambulatory BP monitoring. Quality of life was measured by self–administered questionnaire which contains components such as symptomatic well-being, psychological well-being, sleep dysfunction, sexual dysfunction and cognitive ability.
Results: The dippers (62 patients) and non-dippers (40 patients) were similar with respect to demographic characteristics. Non-dippers compared to dippers had significantly greater office BP (by 12/5 mmHg, p
Non dippers did not show a significant impairment in QOL compared to dippers: Symptomatic well being was present in 38 (61%) non-dippers compared to 33 (83%) dippers (p=NS). Psychological well-being was present in 40 (66%) non dippers compared to 25(60%) dippers (p=NS). Sleep dysfunction was present in 12(19%) non dippers compared to 2(5%) dippers (p=NS). Sexual dysfunction was present in 13(22%) non-dippers compared to 7(17%) dippers (p=NS). The impairment of cognitive ability was present in 9(15%) non-dippers compared to 3(8%) dippers (p=NS).
Despite the increased total 24 hour haemodynamic load the non-dippers hypertensive subjects do not show an impairment of quality of life compared to dippers hypertensive subjects.
120 Relation of Circadian Blood Pressure Variations and Quality of Life in Untreated Essential Hypertensive Subjects