120 Relation Of Circadian Blood Pressure Variations And Quality Of Life In Untreated Essential Hypertensive Subjects

Conference: 
Author(s): 
Anargiros Mariolis
Text: 
Aims: To study the effects of diurnal blood pressure (BP) variations upon quality of life (QOL) in untreated subjects with moderate essential hypertension (EH)
Design and Methods:
Towards this end, 102 subjects (aged 53?11 years) with stage I-II EH were classified as dippers and non-dippers according to the diurnal variation of >10% between mean daytime and night-time systolic and diastolic BP in 24-h non-invasive ambulatory BP monitoring. Quality of life was measured by self–administered questionnaire which contains components such as symptomatic well-being, psychological well-being, sleep dysfunction, sexual dysfunction and cognitive ability.
Results: The dippers (62 patients) and non-dippers (40 patients) were similar with respect to demographic characteristics. Non-dippers compared to dippers had significantly greater office BP (by 12/5 mmHg, p
Non dippers did not show a significant impairment in QOL compared to dippers: Symptomatic well being was present in 38 (61%) non-dippers compared to 33 (83%) dippers (p=NS). Psychological well-being was present in 40 (66%) non dippers compared to 25(60%) dippers (p=NS). Sleep dysfunction was present in 12(19%) non dippers compared to 2(5%) dippers (p=NS). Sexual dysfunction was present in 13(22%) non-dippers compared to 7(17%) dippers (p=NS). The impairment of cognitive ability was present in 9(15%) non-dippers compared to 3(8%) dippers (p=NS).
Conclusions:
Despite the increased total 24 hour haemodynamic load the non-dippers hypertensive subjects do not show an impairment of quality of life compared to dippers hypertensive subjects.
Literature: 
120 Relation of Circadian Blood Pressure Variations and Quality of Life in Untreated Essential Hypertensive Subjects