523 Possibilities Of Prognosis Of The Treatment Efficacy In Rheumatoid Arthritis Patients

Conference: 
Author(s): 
Grygorii Lysenko - Family Medicine department in National Academy of Postgraduate Education, Kiev, Ukraine
L. Khimion - Family Medicine department in National Academy of Postgraduate Education, Kiev, Ukraine
I. Kryklyvyi - Family Medicine department in National Academy of Postgraduate Education, Kiev, Ukraine
Text: 
Poster
A considerable medical and social problem today is the search for prognostic criteria for the treatment efficacy of rheumatoid arthritis (RA) - one of the most widespread inflammatory joints diseases.
We studied the concentration of antibodies to citrullinated cyclic peptides (CCP antibodies) in plasma of 50 RA patients, who were observed at the family medicine department in 2005-2006. antibodies were determined by tests «Immunoscan RA» (Netherlands). Patients were considered CCP-positive with the concentration of antibodies more then 25U/ml, (30-250 U/ml - low concentration, 251-1000U/ml - high, and more than 1000U/ml - very high concentration). All patients after diagnosis were prescribed standard therapy of RA: methotrexate 10-15 mg/week, non-steroidal anti-inflammatory drugs, prednisolone (in some patients) up to 15 mg/day per os. Efficiency of such therapy was evaluated by determination of dynamics of DAS28 (including the amount of painful and swelling joints, ESR, general estimation of arthritis activity by patient) monthly during 6 months of treatment. Sufficient answer for the conducted treatment considered the decline of DAS28 to 3,2 and below and its decrease on 1,2 points in the first 3 months of therapy.
Results. 72% examined RA patients were CCP positive. Among patients with initially high and very high concentration of antibodies (25 patients) in 80% insufficient efficiency of standard RA therapy was determined, while in CCP-negative patients and patients with low concentration of antibodies insufficient efficacy of treatment was observed at only 68% (pConclusion. Possibly, CCP antibodies concentration in RA patients could be used as prognostic criteria of efficacy of standard therapy of RA.
Literature: 
523
POSSIBILITIES OF PROGNOSIS OF THE TREATMENT EFFICACY IN RHEUMATOID ARTHRITIS PATIENTS