875 Clinical Effectiveness Of Influenza Vaccine And Oral Immunomodulators In Chronic Dialysis Patients

Author(s): 
A Christopoulos 1, I Katsarou 2, C Frangidis 2, O Drakoulongona 2
1 General Clinic 'Evagelismos' Patras
2 General State Hospital Of Zakynthos,
General Clinic Evagelismos Patras and General State Hospital Of Zakynthos, Greece, Renal Units
Text: 
Most studies of vaccination responses to T-cell-in depended vaccines (tetanus, diphtheria toxoid, varicella), have indicated that antibody titres in uraemic patients are less than those achieved in the normal host and decline quickly. This is more evident for vaccines against T-cell-depended antigens, such as pneumococci and Haemophilus influenzae or hepatitis B virus.
AIM: To study the clinical effectiveness of influenza vaccine and oral immunomodulators in dialysis patients.
MATERIAL-METHOD:
We recorded all the respiratory tract infections (RTI) and their clinical course in 140 dialysis patients for a six-month period (October-March). Patients were divided in 3 groups. In group A (n= 55) was commenced influenza vaccine. In group B (n=64) were commenced influenza vaccine plus oral immunomodulator Broncho-vaxom (lyophilised bacterial lysate 7 mg/24h). In group C (n=21), were included patients with known allergy or those who denied vaccination and immunomodification.
RESULTS:
No differences were noted in the incidence and the clinical course of RTI between A and C groups (p>0,07). A significant decrease was noted in the incidence of RTI in group B (pCONCLUSION:
Previous studies, demonstrated that influenza vaccination in general population, was followed by a 38-96% decrease in the influenza-like RTI and pneumonias. Such a protection was not verified in our study. In contrast the oral immunomodulator Broncho-vaxom activating natural immunity protected our patients from a variety of viral and bacterial Respiratory tract infections.
Literature: 
875
CLINICAL EFFECTIVENESS OF INFLUENZA VACCINE AND ORAL IMMUNOMODULATORS IN CHRONIC DIALYSIS PATIENTS