AB134         POSTPRANDIAL SERUM LIPID LEVELS AFTER A HIGH LIPID CONTENT MIXED MEAL IN TYPE 2 DIABETIC PATIENTS WITH NORMAL FASTING LIPID LEVELS

Author(s): 
Sayali E, Karadag B, Okyar M, Parkan S
ISTANBUL, TURKEY
Text: 
Background:
Hypertriglyceridaemia in type 2 diabetes is associated with an increased risk for cardiovascular diseases. Recent studies recognize postprandial lipoprotein metabolism to be important for the propensity for atherosclerosis.
Aim: To compare postprandial lipid levels in type 2 diabetic patients with non-diabetic healthy subjects.
Method: 25 type 2 diabetic patients (male/female: 9/16) and 20 non-diabetic subjects as control (male/female: 7/13) were included in our study. After 12 hours of fasting period blood samples for plasma glucose and lipid levels were obtained; and a standardized breakfast was given to both groups. The energy content of this meal was 900 kcal; 50% of the energy was derived from fat, 35% from carbohydrate and 15% from protein. In 2,4,6 hours of postprandial period, plasma glucose and lipid levels were measured. Student-t test was used for statistical analyses.
Results: No statistically significant difference was found concerning age, gender, fasting triglyceride, vldl, ldl and total cholesterol levels between two groups (p>0.05). Hdl levels were significantly lower (p0.5).
Conclusion:
Postprandial peak triglyceride levels in type 2 diabetic patients are significantly higher than in non-diabetic subjects, even if their fasting lipids are in normal range; suggesting the evidence of lipid intolerance in type 2 diabetic patients. Postprandial triglyceride levels should be examined in Addition to fasting lipid levels to assess the risk for cardiovascular diseases in patients with type 2 diabetes.