AB259         PREDICTING THE AGE OF FIRST MYOCARDIAL INFARCTION USING THE 2ND AND 4TH DIGIT RATIO

Author(s): 
Manning J, Bundred P
LIVERPOOL, UK
Text: 
Background:
Traditional risk factors for myocardial infarction (MI) account of testosterone are protective against (MI) in men. The ratio of the length of the 2nd and 4th digit (2D:4D), which is fixed in the first trimester, has been shown to be sexually dimorphic, males have lower 2D:4D or longer 4th digits relative to 2nd, compared with females. Low 2D:4D is associated with high testosterone and low oestrogen concentrations in utero.
Aim: To show a relationship between 2D:4D ratio in men and the development of heart disease in middle life.
Methods: In two studies carried out in general practice on men who had had MI, morphological and clinical data were collected.
Results: In study (1) in a sample of 130 men (mean age at MI 59.90 SD10.47 years), the patients with low 2D:4D in their right hand were older at MI than patients with high 2D:4D (p=0.002, independent of socio-economic status, weight and smoking habits). In study (2) in a sample of 101 men (mean age at MI 59.54 SD 10.74 years), men with low 2D:4D had low systolic blood pressure, high waist:hip ratio (WHR) and were less likely to be prescribed lipid lowering drugs than men with high 2D:4D (systolic blood pressure, right hand p=0.01, left hand p=0.03; WHR right hand p=0.01, left hand p=0.08; lipid-lowering drugs, right hand p=0.0001, left hand p=0.0001: independent of current age of patients).
Conclusions:
The intra-uterine environment may increase the risk of developing heart disease in early middle life. 2D:4D ratio is a simple screening procedure for risk stratification.