Id 1034 Preventive Oral Iron Supplementation For Women During Pregnancy

Guimarães AI, Neves AL, Rolão C
Aim(s) or purpose: Iron deficiency anaemia, the late manifestation of chronic iron deficiency, is thought to be the most common nutrient deficiency among pregnant women. Iron deficiency involves an insufficient supply of iron to the cells following depletion of the body’s reserves. Preventive oral iron supplementation in pregnant women has been widely used. The authors aim to assess the effectiveness of use of iron supplements in healthy pregnant women.
Design and method: A systematic review was performed in the medical databases Medline/Pubmed, Cochrane Library, National Guideline Clearinghouse, Clinical Knowledge Summaries and evidence-based medicine sites, between January 2000 and December 2009, using MeSH keywords Iron, Pregnancy and Dietary Supplements. SOR Taxonomy was used to determine level of evidence and strength of recommendation.
Results: In the research we found 97 articles, but only 7 were included in the review: 2 guidelines, one evidence-based review, two systematic reviews and two clinical trials. After analysing the articles, we found universal prenatal supplementation with iron to be effective in preventing anaemia and iron deficiency at term. We found no evidence, however, of significant reduction in substantive maternal and neonatal adverse clinical outcome, such as low birth weight and pre-term birth.
Conclusions: There is insufficient evidence to recommend for or against routine iron supplementation in non-anaemic pregnant women (SOR A). Clinical trials provided limited information related to clinical maternal and infant outcomes. Instead, most were disease oriented, focusing primarily on maternal changes in haemoglobin. Among included studies, a high level of methodology heterogeneity was found, limiting data interpretation.
ID 1034
Preventive oral iron supplementation for women during pregnancy