Id 353 The Relationship Between Colorectal Adenomatous Polyp And Total Abdominal Fat

Conference: 
Author(s): 
Kim HB, Sim JY
Republic of Korea
hongbai96@naver.com
Text: 
Aim(s) or purpose: Colorectal adenomatous polyp is a precursor lesion of colorectal cancer and there is a study that suggests it may be related to metabolic syndrome, lack of exercise. A few studies attempted to find out an association between colorectal adenomatous polyp and obesity, but results show considerable heterogeneity. Our study aims to investigate the relationship between colorectal polyp and total abdominal fat.
Design and method: 208 colorectal adenoma cases and 924 polyp free controls (male 734, female 398) were gathered in our hospital based health promotion Centre from January 2007 to November 2008. Subjects underwent screening colonoscopy by experienced endoscopists. Blood pressure, BMI, high-density lipoprotein, triglyceride, fasting blood glucose were measured, and total abdominal fat was evaluated by measuring bioelectrical impedance analysis. We examined the relationship between colorectal polyp and abdominal fat by logistic regression analysis in this cross-sectional study. Statistical analysis was performed using SPSS for 15.0.
Results: In female, the prevalence for abdominal obesity was 20 % in the colorectal polyp group and 6.4 % in the control group. In male, the prevalence for abdominal obesity was 24.2 % in the colorectal polyp group and 18.8 % in the control group. After we adjusted the confounding factors that are associated with metabolic syndrome, odd ratio of last quartile of abdominal fat for colorectal polyp was 5.23 (95 % confidence interval 2.24-12.20) when first quartile of abdominal fat was set as a reference.
Conclusions: Our study suggests that total abdominal fat is an important and independent risk factor for colorectal polyp.
Literature: 
ID 353
The relationship between colorectal adenomatous polyp and total abdominal fat