Id 392 Schizophrenia And Bipolar Disease Can Be Successfully Managed With Second-Generation Antipsychotics And Improves The Outpatient Treatment In Family Practice. Results: Of The Serenity Study

Moeremans P, Pitchot W, Taeter C, Duquenne V
Aim(s) or purpose: General Practitioners (GPs) play a central role in the assessment and management of patients with schizophrenia and bipolar disease. This study was designed to investigate the effectiveness of second-generation antipsychotics in a GP-based management setting.
Design and method: Inclusion: Patients between 18–65 years old, diagnosed with schizophrenia or bipolar mania and treated with a second generation antipsychotic drug. Quality of Life (QoL) questionnaire (Q-LES-Q-16), the Sheehan Disability Scale (SDS) for patient well-being, the Clinical Global Impression (CGI-I, Global Improvement) and Patient Global Impression of Change (PGIC) scores for clinical efficacy and tolerability were assessed at Visit 1 (day 0), Visit 2 (week 4) and Visit 3 (week 8).
Results: Between 2007–2008, 252 patients were enrolled in Belgium. Overall, patients were 44 +/- 12 years old, moderately ill (mean CGI-I overall score) with duration of illness of 11 +/- 9 years. The majority of patients completed the study (90 %), withdrawal due to adverse events was only 2.5 %, 6 % due to non-compliance to study protocol and 1 % due to lack of efficacy. Main outcome measures: Q-LES-Q results demonstrated an improvement in the schizophrenic patients’ functioning with a mean change from baseline of 27 (95 % CI 22–32). The SDS total score decreased for all patients showing an improvement in well-being with a mean change from baseline of 29 (CI 211 28). CGI-I and PGIC scores decreased, indicating an improvement in the patient’s condition. A positive correlation was seen between the satisfaction with medication and efficacy, tolerability and well-being. The number of days lost due to illness and the number of unproductive days, at work or school decreased with a mean change of 21.9 and 22.3, respectively.
Conclusions: With second generation antipsychotics, primary care physicians can successfully treat schizophrenic or bipolar patients without hospitalisation. This approach may enable patients to function in society.
ID 392
Schizophrenia and bipolar disease can be successfully managed with second-generation antipsychotics and improves the outpatient treatment in family practice. Results: of the serenity study